Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin

Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin

There is an unmet need for late-stage <sup>18</sup>F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information on the pharmacokinetics/pharmacodynamics (PK/PD)...

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Bibliographic Details
Main Authors: Gonçalo S. Clemente, Tryfon Zarganes-Tzitzikas, Alexander Dömling, Philip H. Elsinga
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
fluorine-18
radiochemistry
late-stage radiofluorination
drug development
copper-catalyzed
boronic pinacol ester
Online Access:https://www.mdpi.com/1420-3049/24/23/4210

Internet

https://www.mdpi.com/1420-3049/24/23/4210

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