Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.

Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.

The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous melanoma, in which the level of FASN expression i...

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Bibliographic Details
Main Authors: Franco A Rossato, Karina G Zecchin, Paolo G La Guardia, Rose M Ortega, Luciane C Alberici, Rute A P Costa, Rodrigo R Catharino, Edgard Graner, Roger F Castilho, Aníbal E Vercesi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4071076?pdf=render

Internet

http://europepmc.org/articles/PMC4071076?pdf=render

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