The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1

The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1

Receptor-interacting protein kinase 1 (RIPK1) is a key component of the tumor necrosis factor (TNF) receptor signaling complex that regulates both pro- and anti-apoptotic signaling. The reciprocal functions of RIPK1 in TNF signaling are determined by the state of the posttranslational modifications...

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Bibliographic Details
Main Authors: Tatsuya Shimada, Yuki Kudoh, Takuya Noguchi, Tomohiro Kagi, Midori Suzuki, Mei Tsuchida, Hiromu Komatsu, Miki Takahashi, Yusuke Hirata, Atsushi Matsuzawa
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
receptor-interacting protein kinase 1 (RIPK1)
Tumor necrosis factor-α (TNF-α)
RING finger protein 4 (RNF4)
TNF receptor-mediated cell death
Online Access:https://www.mdpi.com/1422-0067/22/11/5796

Internet

https://www.mdpi.com/1422-0067/22/11/5796

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