Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents

Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents

The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1<i>H</i>,3<i>H</i>)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (<i>m</i>Mr)...

Full description

Bibliographic Details
Main Authors: Oszkár Csuvik, Nikoletta Szemerédi, Gabriella Spengler, István Szatmári
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
Conrad–Limpach reaction
4-hydroxyquinoline
modified Mannich reaction
Knoevenagel condensation
cytotoxic effect
selective toxicity towards MDR cancer
Online Access:https://www.mdpi.com/1422-0067/23/17/9688

Internet

https://www.mdpi.com/1422-0067/23/17/9688

Similar Items