A Novel Hydrogel-Based 3D In Vitro Tumor Panel of 30 PDX Models Incorporates Tumor, Stromal and Immune Cell Compartments of the TME for the Screening of Oncology and Immuno-Therapies

A Novel Hydrogel-Based 3D In Vitro Tumor Panel of 30 PDX Models Incorporates Tumor, Stromal and Immune Cell Compartments of the TME for the Screening of Oncology and Immuno-Therapies

Human-relevant systems that mimic the 3D tumor microenvironment (TME), particularly the complex mechanisms of immuno-modulation in the tumor stroma, in a reproducible and scalable format are of high interest for the drug discovery industry. Here, we describe a novel 3D in vitro tumor panel comprisin...

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Bibliographic Details
Main Authors: Bin Xue, Julia Schüler, Christopher M. Harrod, Kanstantsin Lashuk, Zoji Bomya, Kolin C. Hribar
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
three dimensional models
3D cell culture
patient-derived xenograft
tumor panel
drug screening
immuno-oncology
Online Access:https://www.mdpi.com/2073-4409/12/8/1145

Internet

https://www.mdpi.com/2073-4409/12/8/1145

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