Ciprofloxacin and pegylated G-CSF combined therapy mitigates brain hemorrhage and mortality induced by ionizing irradiation

Ciprofloxacin and pegylated G-CSF combined therapy mitigates brain hemorrhage and mortality induced by ionizing irradiation

IntroductionBrain hemorrhage was found between 13 and 16 days after acute whole-body 9.5 Gy 60Co-γ irradiation (IR). This study tested countermeasures mitigating brain hemorrhage and increasing survival from IR. Previously, we found that pegylated G-CSF therapy (PEG) (i.e., Neulasta®, an FDA-approve...

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Bibliographic Details
Main Authors: Juliann G. Kiang, Georgetta Cannon, Matthew G. Olson, Min Zhai, Akeylah K. Woods, Feng Xu, Bin Lin, Xianghong Li, Lisa Hull, Suping Jiang, Mang Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Public Health
Subjects:
mouse
Ciprofloxacin
G-CSF
radiation
platelet
glial fibrillary acidic protein
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2023.1268325/full

Internet

https://www.frontiersin.org/articles/10.3389/fpubh.2023.1268325/full

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