An Oxidant-Free and Mild Strategy for Quinazolin-4(3<i>H</i>)-One Synthesis via CuAAC/Ring Cleavage Reaction

An Oxidant-Free and Mild Strategy for Quinazolin-4(3<i>H</i>)-One Synthesis via CuAAC/Ring Cleavage Reaction

An oxidant-free and highly efficient synthesis of phenolic quinazolin-4(3<i>H</i>)-ones was achieved by simply stirring a mixture of 2-aminobenzamides, sulfonyl azides, and terminal alkynes. The intermediate <i>N</i>-sulfonylketenimine underwent two nucleophilic additions and...

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Bibliographic Details
Main Authors: Yueling He, Zhongtao Yang, Danyang Luo, Xiai Luo, Xiaodong Chen, Weiguang Yang
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
CuAAC/ring cleavage reaction
nucleophilic addition
natural product
quinazolin-4(<i>3H</i>)-ones
ketenimine
Online Access:https://www.mdpi.com/1420-3049/28/15/5734

Internet

https://www.mdpi.com/1420-3049/28/15/5734

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