A joint transcriptional regulatory network and protein activity inference analysis identifies clinically associated master regulators for biliary atresia

A joint transcriptional regulatory network and protein activity inference analysis identifies clinically associated master regulators for biliary atresia

Biliary atresia (BA) is a devastating cholangiopathy in neonate. Transcription factors (TFs), a type of master regulators in biological processes and diseases, have been implicated in pathogenesis of BA. However, a global view of TFs and how they link to clinical presentations remain explored. Here,...

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Bibliographic Details
Main Authors: Panpan Sun, Manhuan Xiao, Huadong Chen, Zhihai Zhong, Hong Jiang, Xuyang Feng, Zhenhua Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pediatrics
Subjects:
pediatric
cholangiopathy
deconvolution
transcription factor
network
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.1050326/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2022.1050326/full

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