Mechanistic Insights into the Inhibition of a Common CTLA-4 Gene Mutation in the Cytoplasmic Domain

Mechanistic Insights into the Inhibition of a Common CTLA-4 Gene Mutation in the Cytoplasmic Domain

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a pivotal immune checkpoint receptor, playing a crucial role in modulating T-cell activation. In this study, we delved into the underlying mechanism by which a common mutation, G199R, in the cytoplasmic domain of CTLA-4 impacts its inhibitory function. Ut...

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Bibliographic Details
Main Authors: Jikang Xu, Yu Zhang, Lijuan Shen, Lingyu Du, Hongjuan Xue, Bin Wu, Bo OuYang
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
CTLA-4
G199R
NMR spectroscopy
lipid regulation
inhibitory mechanism
Online Access:https://www.mdpi.com/1420-3049/29/6/1330

Internet

https://www.mdpi.com/1420-3049/29/6/1330

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