Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes

Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes

BackgroundGlucose metabolism, specifically, hexokinase 2 (HK2), has a critical role in rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) phenotype. HK2 localizes not only in the cytosol but also in the mitochondria, where it protects mitochondria against stress. We hypothesize that mitocho...

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Bibliographic Details
Main Authors: Alyssa Torres, Sarah Kang, Christopher B. Mahony, Martha Cedeño, Patricia G. Oliveira, Marta Fernandez-Bustamante, Samuel Kemble, Teresina Laragione, Percio S. Gulko, Adam P. Croft, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
FLS
mitochondria
glucose metabolism
hexokinase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103231/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103231/full

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