Impaired spatial memory codes in a mouse model of Rett syndrome

The Mecp2+/- mouse model recapitulates many phenotypes of patients with Rett syndrome (RTT), including learning and memory deficits. It is unknown, however, how the disease state alters memory circuit functions in vivo in RTT mice. Here we recorded from hippocampal place cells, which are thought to...

Full description

Bibliographic Details
Main Authors: Sara E Kee, Xiang Mou, Huda Y Zoghbi, Daoyun Ji
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/31451