4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors

4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors

Acid-sensing ion channels (ASICs) play a key role in the perception and response to extracellular acidification changes. These proton-gated cation channels are critical for neuronal functions, like learning and memory, fear, mechanosensation and internal adjustments like synaptic plasticity. Moreove...

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Bibliographic Details
Main Authors: Maksym Platonov, Oleksandr Maximyuk, Alexey Rayevsky, Vasyl Hurmach, Olena Iegorova, Vasyl Naumchyk, Elijah Bulgakov, Andrii Cherninskyi, Danil Ozheredov, Serhiy V. Ryabukhin, Oleg Krishtal, Dmytro M. Volochnyuk
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
acid-sensitive ion channel
virtual screening
drug discovery
screening assay
automated patch clamp
Online Access:https://www.mdpi.com/1422-0067/25/7/3584

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https://www.mdpi.com/1422-0067/25/7/3584

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