Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug–polymer ratios were...

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Bibliographic Details
Main Authors: Amir Ibrahim Mohamed, Amr Mohamed Elsayed Abd-Motagaly, Osama A. A. Ahmed, Suzan Amin, Alaa Ibrahim Mohamed Ali
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Pharmaceutics
Subjects:
clindamycin HCl
sodium alginate
chitosan
partial least squares regression (PLS)
drug–polymer compatibility
Online Access:http://www.mdpi.com/1999-4923/9/1/7

Internet

http://www.mdpi.com/1999-4923/9/1/7

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