Heterologous Immune Responses of Serum IgG and Secretory IgA Against the Spike Protein of Endemic Coronaviruses During Severe COVID-19

Heterologous Immune Responses of Serum IgG and Secretory IgA Against the Spike Protein of Endemic Coronaviruses During Severe COVID-19

Defining immune correlates of disease severity is important to better understand the immunopathogenesis in COVID-19. Here we made use of a protein microarray platform to detect IgG- and IgA-reactive antibodies in sera and saliva respectively, and assess cross-reactivity between SARS-CoV-2 and endemi...

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Bibliographic Details
Main Authors: Wouter L. Smit, Sophie van Tol, Sanne van der Wal, Femke van Vulpen, Shannon la Grouw, Lenneke van Lelyveld, Gijs Limonard, Ailko Bossink, Gert-Jan Godeke, Sandhya Shrestha, Johan Reimerink, Dirk Eggink, Chantal Reusken, Michiel Heron, Steven Thijsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
spike protein
seasonal coronaviruses
immune imprinting
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.839367/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.839367/full

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