Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

<p>Abstract</p> <p>Background</p> <p>A deficiency in <it>Perk </it>(EIF2AK3) causes multiple neonatal defects in humans known as the Wolcott Rallison syndrome. <it>Perk KO </it>mice exhibit the same array of defects including permanent neonatal d...

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Bibliographic Details
Main Authors: McGrath Barbara C, Gupta Sounak, Wei Jianwen, Feng Daorong, Cavener Douglas R
Format: Article
Language:English
Published: BMC 2009-09-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/10/61

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