Polyvinyl alcohol extrudates for improving the dissolution of main protease and reverse-transcriptase inhibitors.

Polyvinyl alcohol extrudates for improving the dissolution of main protease and reverse-transcriptase inhibitors.

The aim of this work was to improve the solubility of various anti-HIV APIs extruding them with polyvinyl alcohol to allow a reduction in patient drug burden. There are no previously known cases of successful use of this polymer to improve the solubility of APIs using a convenient industrial technol...

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Bibliographic Details
Main Authors: Sergey A Zolotov, Natalia B Demina, Igor A Dain, Anna S Zolotova, Grigorii A Buzanov, Vasilii M Retivov, Alexander M Cheremisin
Format: Article
Language:English
Published: International Pharmaceutical Excipients Council 2022-03-01
Series:Journal of Excipients and Food Chemicals
Online Access:https://jefc.scholasticahq.com/article/33911-polyvinyl-alcohol-extrudates-for-improving-the-dissolution-of-main-protease-and-reverse-transcriptase-inhibitors

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https://jefc.scholasticahq.com/article/33911-polyvinyl-alcohol-extrudates-for-improving-the-dissolution-of-main-protease-and-reverse-transcriptase-inhibitors

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