The effect of postmenopausal osteoporosis on subchondral bone pathology in a rat model of knee osteoarthritis

Abstract This study aimed to investigate the additional effect of ovariectomy-induced osteoporosis (OP) on the pathology of knee osteoarthritis (OA) in a rat meniscectomized model, particularly focusing on subchondral bone changes and pain behaviour. Rats were divided into four groups, sham, OP, OA,...

Full description

Bibliographic Details
Main Authors: Hiroyuki Wada, Koji Aso, Masashi Izumi, Masahiko Ikeuchi
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-29802-7