Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice

Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice

ABSTRACTCytoplasmic FMR1-interacting protein 2 (CYFIP2) is an evolutionarily conserved multifunctional protein that regulates the neuronal actin cytoskeleton, mRNA translation and transport, and mitochondrial morphology and function. Supporting its critical roles in proper neuronal development and f...

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Bibliographic Details
Main Authors: Ruiying Ma, Yinhua Zhang, Huiling Li, Hyae Rim Kang, Yoonhee Kim, Kihoon Han
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Animal Cells and Systems
Subjects:
CYFIP2
Alzheimer’s disease
hippocampal CA1
excitatory pyramidal neuron
conditional knock-out
Online Access:https://www.tandfonline.com/doi/10.1080/19768354.2023.2192263

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https://www.tandfonline.com/doi/10.1080/19768354.2023.2192263

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