Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity

Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity

3,4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug, however over 200 studies demonstrate that acute (e.g. hyperthermia, rhabdomyolysis) and chronic (e.g. neurotoxicity) toxicity effects of MDMA were observed in different animals. Methimazole (MMI), an inhibitor of thyroid hormon...

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Bibliographic Details
Main Authors: I-Hsun Li, Tsung-Ta Liu, Ying-Chen Chen, Sheng-Huang Hsiao, Hao-Yuan Hung, Li-Yun Fann, Jui-Hu Shih
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Methimazole
MDMA
Hyperthermia
PET
Serotonergic neurotoxicity
Forced swimming test
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223006704

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http://www.sciencedirect.com/science/article/pii/S0753332223006704

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