Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation
Amino acid deprivation increases ACE2 expression in the gut, potentially aggravating SARS-CoV-2 infection.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03609-0 |
| _version_ | 1811328712226897920 |
|---|---|
| author | Xiaoming Hu Yuguo Niu Peixiang Luo Fei Xiao Feixiang Yuan Hanrui Yin Shanghai Chen Feifan Guo |
| author_facet | Xiaoming Hu Yuguo Niu Peixiang Luo Fei Xiao Feixiang Yuan Hanrui Yin Shanghai Chen Feifan Guo |
| author_sort | Xiaoming Hu |
| collection | DOAJ |
| description | Amino acid deprivation increases ACE2 expression in the gut, potentially aggravating SARS-CoV-2 infection. |
| first_indexed | 2024-04-13T15:30:54Z |
| format | Article |
| id | doaj.art-56e193e716e343c5bbbaae238ba2a998 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T15:30:54Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-56e193e716e343c5bbbaae238ba2a9982022-12-22T02:41:23ZengNature PortfolioCommunications Biology2399-36422022-07-01511810.1038/s42003-022-03609-0Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivationXiaoming Hu0Yuguo Niu1Peixiang Luo2Fei Xiao3Feixiang Yuan4Hanrui Yin5Shanghai Chen6Feifan Guo7Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityZhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesZhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityZhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesZhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityZhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan UniversityAmino acid deprivation increases ACE2 expression in the gut, potentially aggravating SARS-CoV-2 infection.https://doi.org/10.1038/s42003-022-03609-0 |
| spellingShingle | Xiaoming Hu Yuguo Niu Peixiang Luo Fei Xiao Feixiang Yuan Hanrui Yin Shanghai Chen Feifan Guo Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation Communications Biology |
| title | Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation |
| title_full | Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation |
| title_fullStr | Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation |
| title_full_unstemmed | Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation |
| title_short | Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation |
| title_sort | amino acid sensor gcn2 promotes sars cov 2 receptor ace2 expression in response to amino acid deprivation |
| url | https://doi.org/10.1038/s42003-022-03609-0 |
| work_keys_str_mv | AT xiaominghu aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation AT yuguoniu aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation AT peixiangluo aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation AT feixiao aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation AT feixiangyuan aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation AT hanruiyin aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation AT shanghaichen aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation AT feifanguo aminoacidsensorgcn2promotessarscov2receptorace2expressioninresponsetoaminoaciddeprivation |