Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli

Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli

Lamotrigine (Ltg), an anticonvulsant drug, targets initiation factor 2 (IF2), compromises ribosome biogenesis and causes toxicity to Escherichia coli. However, our understanding of Ltg toxicity in E. coli remains unclear. While our in vitro assays reveal no effects of Ltg on the ribosome-dependent G...

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Bibliographic Details
Main Authors: Sudhir Singh, Kuldeep Lahry, Chandra Sekhar Mandava, Jitendra Singh, Riyaz Ahmad Shah, Suparna Sanyal, Umesh Varshney
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:RNA Biology
Subjects:
ribosome
lamotrigine
ltg
initiation factor 2
initiator trna
Online Access:http://dx.doi.org/10.1080/15476286.2023.2253395

Internet

http://dx.doi.org/10.1080/15476286.2023.2253395

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