Inhibition of Anti-Inflammatory Macrophage Phenotype Reduces Tumour Growth in Mouse Models of Brain Metastasis

Inhibition of Anti-Inflammatory Macrophage Phenotype Reduces Tumour Growth in Mouse Models of Brain Metastasis

Breast cancer brain metastasis is a significant clinical problem and carries a poor prognosis. Although it is well-established that macrophages are a primary component of the brain metastasis microenvironment, the role of blood-derived macrophages (BDM) and brain-resident microglia in the progressio...

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Bibliographic Details
Main Authors: Vasiliki Economopoulos, Maria Pannell, Vanessa A. Johanssen, Helen Scott, Kleopatra E. Andreou, James R. Larkin, Nicola R. Sibson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
neuro-oncology
tumour microenvironment
brain metastasis
microglia
tumour associated macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.850656/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.850656/full

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