Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin

Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin

The Bordetella pertussis toxin (PT) is one important virulence factor causing the severe childhood disease whooping cough which still accounted for approximately 63,000 deaths worldwide in children in 2013. PT consists of PTS1, the enzymatically active (A) subunit and a non-covalently linked pentame...

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Bibliographic Details
Main Authors: Katharina Ernst, Nina Eberhardt, Ann-Katrin Mittler, Michael Sonnabend, Anna Anastasia, Simon Freisinger, Cordelia Schiene-Fischer, Miroslav Malešević, Holger Barth
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Toxins
Subjects:
pertussis toxin
whooping cough
cellular uptake
membrane transport
cyclosporine A
cyclophilins
chaperones
novel drug targets
Online Access:http://www.mdpi.com/2072-6651/10/5/181

Internet

http://www.mdpi.com/2072-6651/10/5/181

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