Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.

Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.

Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious diseases. PD-1 and CTLA-4 have been extensively studied, and blocking antibodies have already shown clinical benefit for cancer patients. Only little is known on extended co-expression of inhibitory receptors an...

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Bibliographic Details
Main Authors: Lukas Baitsch, Amandine Legat, Leticia Barba, Silvia A Fuertes Marraco, Jean-Paul Rivals, Petra Baumgaertner, Céline Christiansen-Jucht, Hanifa Bouzourene, Donata Rimoldi, Hanspeter Pircher, Nathalie Rufer, Maurice Matter, Olivier Michielin, Daniel E Speiser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3275569?pdf=render

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http://europepmc.org/articles/PMC3275569?pdf=render

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