Cardiorenal Protective Effect of Costunolide against Doxorubicin-Induced Toxicity in Rats by Modulating Oxidative Stress, Inflammation and Apoptosis

Cardiorenal Protective Effect of Costunolide against Doxorubicin-Induced Toxicity in Rats by Modulating Oxidative Stress, Inflammation and Apoptosis

Doxorubicin (DXB) is one of the most commonly used anticancer agents for treating solid and hematological malignancies; however, DXB-induced cardiorenal toxicity presents a limiting factor to its clinical usefulness in cancer patients. Costunolide (COST) is a naturally occurring sesquiterpene lacton...

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Bibliographic Details
Main Authors: Wen Xing, Chaoling Wen, Deguo Wang, Hui Shao, Chunhong Liu, Chunling He, Opeyemi Joshua Olatunji
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
costunolide
cardiorenal protection
doxorubicin
oxidative stress
antioxidant
Online Access:https://www.mdpi.com/1420-3049/27/7/2122

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https://www.mdpi.com/1420-3049/27/7/2122

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