In silico analysis of HIV-1 Env-gp120 reveals structural bases for viral adaptation in growth-restrictive cells

In silico analysis of HIV-1 Env-gp120 reveals structural bases for viral adaptation in growth-restrictive cells

Variable V1/V2 and V3 loops on human immunodeficiency virus type 1 (HIV-1) envelope-gp120 core play key roles in modulating viral competence to recognize two infection receptors, CD4 and chemokine-receptors. However, molecular bases for the modulation largely remain unclear. To address these issues,...

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Bibliographic Details
Main Authors: Masaru eYokoyama, Masako eNomaguchi, Naoya eDoi, Tadahito eKanda, Akio eAdachi, Hironori eSato
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Microbiology
Subjects:
Homology Modeling
MD simulation
V3 loop
Adaptive mutation
V1/V2 loop
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00110/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00110/full

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