Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.

Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.

Cdc42 of the Rho GTPase family has been implicated in cell actin organization, proliferation, survival, and migration but its physiological role is likely cell-type specific. By a T cell-specific deletion of Cdc42 in mouse, we have recently shown that Cdc42 maintains naïve T cell homeostasis through...

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Bibliographic Details
Main Authors: Fukun Guo, Shuangmin Zhang, Pulak Tripathi, Jochen Mattner, James Phelan, Alyssa Sproles, Jun Mo, Marsha Wills-Karp, H Leighton Grimes, David Hildeman, Yi Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3063799?pdf=render

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http://europepmc.org/articles/PMC3063799?pdf=render

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