Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors

Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7. This conversion inactivates the vasoconstrictive...

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Bibliographic Details
Main Authors: Daniel eClayton, Iresha eHanchapola, Walter Glen Thomas, Robert eWiddop, Alexander Ian Smith, Patrick ePerlmutter, Marie-Isabel eAguilar
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Pharmacology
Subjects:
Angiotensin II
Angiotensin II receptor 1
Angiotensin converting enzyme-2
angiotensin II receptor 2
-amino acids
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00005/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00005/full

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