Expression and Function of IL12/23 Related Cytokine Subunits (p35, p40, and p19) in Giant-Cell Arteritis Lesions: Contribution of p40 to Th1- and Th17-Mediated Inflammatory Pathways

Expression and Function of IL12/23 Related Cytokine Subunits (p35, p40, and p19) in Giant-Cell Arteritis Lesions: Contribution of p40 to Th1- and Th17-Mediated Inflammatory Pathways

BackgroundGiant-cell arteritis (GCA) is considered a T helper (Th)1- and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-inflammatory cytokine that maintains Th17 resp...

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Main Authors: Georgina Espígol-Frigolé, Ester Planas-Rigol, Ester Lozano, Marc Corbera-Bellalta, Nekane Terrades-García, Sergio Prieto-González, Ana García-Martínez, Jose Hernández-Rodríguez, Josep M. Grau, Maria C. Cid
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
giant-cell arteritis
Th1/Th17 cytokines
IL-12/23 p40
IL-23p19
IL-12p35
glucocorticoid
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00809/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00809/full

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