The transdermal cream of Formestane anti-breast cancer by controlling PI3K-Akt pathway and the tumor immune microenvironment

The transdermal cream of Formestane anti-breast cancer by controlling PI3K-Akt pathway and the tumor immune microenvironment

BackgroundTreatment of ER+ breast cancer with intramuscular formulation of Formestane (4-OHA) shrinks the tumor within weeks. Since the tedious way of intramuscular administration and side effects are not suited for adjuvant treatment, Formestane was withdrawn from the market. A new transdermal form...

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Bibliographic Details
Main Authors: Lanyang Gao, Lei Zhu, Chen Shen, Xiaoming Hou, Youyou Chen, Linglin Zou, Huiyan Qiang, Alexander T. Teichmann, Wenguang Fu, Yao Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
Formestane cream
DMBA-induced mammary cancer
PI3K-Akt signaling pathway
tumor immune microenvironment
RNA transcriptome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1041525/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1041525/full

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