Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration

Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration

Objective: To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid malabsorption in the small intestine (SI), accompanied by macrophage infiltration, is one of the most common pa...

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Bibliographic Details
Main Authors: Valentina Bianco, Melanie Korbelius, Nemanja Vujic, Alena Akhmetshina, Melina Amor, Dagmar Kolb, Anita Pirchheim, Ivan Bradic, Katharina B. Kuentzel, Martin Buerger, Silvia Schauer, Huyen T.T. Phan, Dominik Bulfon, Gerald Hoefler, Robert Zimmermann, Dagmar Kratky
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Molecular Metabolism
Subjects:
Lysosomal acid lipase
LAL-D
Small intestine
Enterocytes
Intestinal lipid absorption
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000716

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http://www.sciencedirect.com/science/article/pii/S2212877823000716

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