Ionic Regulation of T-Cell Function and Anti-Tumour Immunity
The capacity of T cells to identify and kill cancer cells has become a central pillar of immune-based cancer therapies. However, T cells are characterized by a dysfunctional state in most tumours. A major obstacle for proper T-cell function is the metabolic constraints posed by the tumour microenvir...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/24/13668 |
| _version_ | 1797503735090380800 |
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| author | Pierpaolo Ginefra Helen Carrasco Hope Mattia Spagna Alessandra Zecchillo Nicola Vannini |
| author_facet | Pierpaolo Ginefra Helen Carrasco Hope Mattia Spagna Alessandra Zecchillo Nicola Vannini |
| author_sort | Pierpaolo Ginefra |
| collection | DOAJ |
| description | The capacity of T cells to identify and kill cancer cells has become a central pillar of immune-based cancer therapies. However, T cells are characterized by a dysfunctional state in most tumours. A major obstacle for proper T-cell function is the metabolic constraints posed by the tumour microenvironment (TME). In the TME, T cells compete with cancer cells for macronutrients (sugar, proteins, and lipid) and micronutrients (vitamins and minerals/ions). While the role of macronutrients in T-cell activation and function is well characterized, the contribution of micronutrients and especially ions in anti-tumour T-cell activities is still under investigation. Notably, ions are important for most of the signalling pathways regulating T-cell anti-tumour function. In this review, we discuss the role of six biologically relevant ions in T-cell function and in anti-tumour immunity, elucidating potential strategies to adopt to improve immunotherapy via modulation of ion metabolism. |
| first_indexed | 2024-03-10T03:54:34Z |
| format | Article |
| id | doaj.art-5703a007b8e1451fa9193feaae32cc74 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:54:34Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5703a007b8e1451fa9193feaae32cc742023-11-23T08:49:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241366810.3390/ijms222413668Ionic Regulation of T-Cell Function and Anti-Tumour ImmunityPierpaolo Ginefra0Helen Carrasco Hope1Mattia Spagna2Alessandra Zecchillo3Nicola Vannini4Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066 Epalinges, SwitzerlandDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066 Epalinges, SwitzerlandDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066 Epalinges, SwitzerlandDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066 Epalinges, SwitzerlandDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 1066 Epalinges, SwitzerlandThe capacity of T cells to identify and kill cancer cells has become a central pillar of immune-based cancer therapies. However, T cells are characterized by a dysfunctional state in most tumours. A major obstacle for proper T-cell function is the metabolic constraints posed by the tumour microenvironment (TME). In the TME, T cells compete with cancer cells for macronutrients (sugar, proteins, and lipid) and micronutrients (vitamins and minerals/ions). While the role of macronutrients in T-cell activation and function is well characterized, the contribution of micronutrients and especially ions in anti-tumour T-cell activities is still under investigation. Notably, ions are important for most of the signalling pathways regulating T-cell anti-tumour function. In this review, we discuss the role of six biologically relevant ions in T-cell function and in anti-tumour immunity, elucidating potential strategies to adopt to improve immunotherapy via modulation of ion metabolism.https://www.mdpi.com/1422-0067/22/24/13668T cellionstumour microenvironmentimmunomodulationnutrient competition |
| spellingShingle | Pierpaolo Ginefra Helen Carrasco Hope Mattia Spagna Alessandra Zecchillo Nicola Vannini Ionic Regulation of T-Cell Function and Anti-Tumour Immunity International Journal of Molecular Sciences T cell ions tumour microenvironment immunomodulation nutrient competition |
| title | Ionic Regulation of T-Cell Function and Anti-Tumour Immunity |
| title_full | Ionic Regulation of T-Cell Function and Anti-Tumour Immunity |
| title_fullStr | Ionic Regulation of T-Cell Function and Anti-Tumour Immunity |
| title_full_unstemmed | Ionic Regulation of T-Cell Function and Anti-Tumour Immunity |
| title_short | Ionic Regulation of T-Cell Function and Anti-Tumour Immunity |
| title_sort | ionic regulation of t cell function and anti tumour immunity |
| topic | T cell ions tumour microenvironment immunomodulation nutrient competition |
| url | https://www.mdpi.com/1422-0067/22/24/13668 |
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