Synthesis and Identification of New <i>N</i>,<i>N</i>-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor

Synthesis and Identification of New <i>N</i>,<i>N</i>-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor

Synthesis of thiazolidinone based on quinolone moiety was established starting from 4-hydroxyquinol-2-ones. The strategy started with the reaction of ethyl bromoacetate with 4-hydroxyquinoline to give the corresponding ethyl oxoquinolinyl acetates, which reacted with hydrazine hydrate to afford the...

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Bibliographic Details
Main Authors: Yaseen A. M. M. Elshaier, Ashraf A. Aly, Mohamed Abdel-Aziz, Hazem M. Fathy, Alan B. Brown, Stefan Bräse, Mohamed Ramadan
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
<i>N</i>,<i>N</i>-disubstituted thioureas
dialkyl acetylenedicarboxylates
thiazolidinones
in vitro urease inhibition properties
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/20/7126

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https://www.mdpi.com/1420-3049/27/20/7126

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