Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth—An Investigation of the Activation Mechanism and Their Nanoformulation

Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth—An Investigation of the Activation Mechanism and Their Nanoformulation

The use of platinum-based anticancer drugs, such as cisplatin, oxaliplatin, and carboplatin, is a common frontline option in cancer management, but they have debilitating side effects and can lead to drug resistance. Combination therapy with other chemotherapeutic agents, such as capecitabine and ge...

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Bibliographic Details
Main Authors: Carlo Marotta, Damiano Cirri, Ioannis Kanavos, Luisa Ronga, Ryszard Lobinski, Tiziana Funaioli, Chiara Giacomelli, Elisabetta Barresi, Maria Letizia Trincavelli, Tiziano Marzo, Alessandro Pratesi
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Pharmaceutics
Subjects:
Pt(IV)-based complexes
gemcitabine
capecitabine
PLGA nanoparticles
anticancer drugs
colorectal cancer
Online Access:https://www.mdpi.com/1999-4923/16/2/278

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https://www.mdpi.com/1999-4923/16/2/278

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