AKAP79 enables calcineurin to directly suppress protein kinase A activity

AKAP79 enables calcineurin to directly suppress protein kinase A activity

Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosphorylates sites primed by PKA to bring about chang...

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Bibliographic Details
Main Authors: Timothy W Church, Parul Tewatia, Saad Hannan, João Antunes, Olivia Eriksson, Trevor G Smart, Jeanette Hellgren Kotaleski, Matthew G Gold
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
protein kinase A
anchoring protein
synaptic plasticity
calcineurin
cyclic AMP
calcium
Online Access:https://elifesciences.org/articles/68164

Internet

https://elifesciences.org/articles/68164

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