Anus preservation in low rectal adenocarcinoma based on MMR/MSI status (APRAM): a study protocol for a randomised, controlled, open-label, multicentre phase III trial

Anus preservation in low rectal adenocarcinoma based on MMR/MSI status (APRAM): a study protocol for a randomised, controlled, open-label, multicentre phase III trial

Abstract Background Anus preservation has been a challenge in the treatment of patients with low rectal adenocarcinoma (within 5 cm from the anal verge) because it is difficult to spare the anus with its functioning sphincter complex under the safe margin of tumour resection. Patients with dMMR/MSI-...

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Bibliographic Details
Main Authors: Cheng-Yi Huang, Ming-Hua Bai, Jin-Wen Shen, Quan-Quan Sun, Yan-Ru Feng, Qian-Ping Chen, Wei Mao, Hai-Xing Ju, Ji Zhu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Cancer
Subjects:
Rectal cancer
Anus preservation
Chemotherapy
Radiotherapy
Immunotherapy
MMR/MSI status
Online Access:https://doi.org/10.1186/s12885-024-11829-2

Internet

https://doi.org/10.1186/s12885-024-11829-2

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