NPRL2 down‐regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression

NPRL2 down‐regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression

Abstract Hepatocellular carcinoma (HCC) is a highly invasive malignancy. Recently, GATOR1 (Gap Activity TOward Rags 1) complexes have been shown to play an important role in regulating tumor growth. NPRL2 is a critical component of the GATOR1 complex. Therefore, this study used NPRL2 knockdown to in...

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Bibliographic Details
Main Authors: Ya‐Chin Wang, Ming‐Chao Tsai, Yaw‐Sen Chen, Pei‐Min Hsieh, Chao‐Ming Hung, Hung‐Yu Lin, Yao‐Chun Hsu, Jen‐Hao Yeh, Pojen Hsiao, Yu‐Cheih Su, Ching‐Hou Ma, Chih‐Yuan Lee, Chih‐Che Lin, Chih‐Wen Shu, Yu‐Chan Li, Mei‐Hsing Tsai, James Yu Lin, Wei‐Hao Peng, Ming‐Lung Yu, Chih‐Wen Lin
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2022-12-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.2019

Internet

https://doi.org/10.1002/hep4.2019

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