Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice

Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice

Abstract Background Overexpression of apolipoprotein CIII (ApoCIII) leads to hypertriglyceridemia (HTG) which promotes atherosclerosis development. However, it remains unclear whether ApoCIII affects the atherosclerosis alone by promoting the inflammation and endoplasmic reticulum (ER) stress, or in...

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Bibliographic Details
Main Authors: Han Yingchun, Ma Yahong, Wen Jiangping, He Xiaokui, Zhang Xiaohong
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Lipids in Health and Disease
Subjects:
Apolipoprotein CIII
Triglyceride-rich lipoprotein
Endothelial cells
Macrophages
Inflammation
Endoplasmic reticulum stress
Online Access:http://link.springer.com/article/10.1186/s12944-018-0867-5

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http://link.springer.com/article/10.1186/s12944-018-0867-5

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