Truncated Milk Fat Globule-EGF-like Factor 8 Ameliorates Liver Fibrosis via Inhibition of Integrin-TGFβ Receptor Interaction

Truncated Milk Fat Globule-EGF-like Factor 8 Ameliorates Liver Fibrosis via Inhibition of Integrin-TGFβ Receptor Interaction

Milk fat globule-EGF factor 8 (MFG-E8) protein is known as an immunomodulator in various diseases, and we previously demonstrated the anti-fibrotic role of MFG-E8 in liver disease. Here, we present a truncated form of MFG-E8 that provides an advanced therapeutic benefit in treating liver fibrosis. T...

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Bibliographic Details
Main Authors: Geun Ho An, Jaehun Lee, Xiong Jin, Jinwoo Chung, Joon-Chul Kim, Jung-Hyuck Park, Minkyung Kim, Choongseong Han, Jong-Hoon Kim, Dong-Hun Woo
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomedicines
Subjects:
liver fibrosis
liver disease
protein therapy
integrin
TGF-β
Online Access:https://www.mdpi.com/2227-9059/9/11/1529

Internet

https://www.mdpi.com/2227-9059/9/11/1529

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