Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection

Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection

Abstract Background The genomes of HIV-2 and some SIV strains contain the accessory gene vpx, which carries out several functions during infection, including the downregulation of SAMHD1. Vpx is also commonly used in experiments to increase HIV-1 infection efficiency in myeloid cells, particularly i...

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Bibliographic Details
Main Authors: Oya Cingöz, Nicolas D. Arnow, Mireia Puig Torrents, Norbert Bannert
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Retrovirology
Subjects:
Infection
Innate immunity
Interferon
MDM
Macrophage
THP-1
Online Access:https://doi.org/10.1186/s12977-021-00548-2

Internet

https://doi.org/10.1186/s12977-021-00548-2

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