CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

To investigate how the CARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous Card14E138A mutation from the endogenous mouse Card14 locus. Heterozygous expression of CARD14E138A rapidly ind...

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Bibliographic Details
Main Authors: Joan Manils, Louise V Webb, Ashleigh Howes, Julia Janzen, Stefan Boeing, Anne M Bowcock, Steven C Ley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
CARD14
psoriasis
nf-kb
inflammation
TNF
keratinocytes
Online Access:https://elifesciences.org/articles/56720

Internet

https://elifesciences.org/articles/56720

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