The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands, CD80 and CD86, could support the development of...

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Bibliographic Details
Main Authors: Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Epigenetics
Subjects:
cd28
cd80
cd86
ctla4
icos
dna methylation
immune checkpoint
hnscc
prognosis
tumour microenvironment
hpv
Online Access:http://dx.doi.org/10.1080/15592294.2020.1754675

Internet

http://dx.doi.org/10.1080/15592294.2020.1754675

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