Activation of angiotensin-converting enzyme 2 ameliorates metabolic syndrome-induced renal damage in rats by renal TLR4 and nuclear transcription factor κB downregulation

Activation of angiotensin-converting enzyme 2 ameliorates metabolic syndrome-induced renal damage in rats by renal TLR4 and nuclear transcription factor κB downregulation

BackgroundMetabolic syndrome (MetS) is an independent risk factor for chronic kidney disease (CKD) through many mechanisms, including activation of the renin–angiotensin system. The deleterious effects of angiotensin II (Ang II) can be counterbalanced by angiotensin-converting enzyme 2 (ACE2). Dimin...

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Bibliographic Details
Main Authors: Heba F. El-Domiaty, Eman Sweed, Mona A. Kora, Nader G. Zaki, Suzan A. Khodir
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Medicine
Subjects:
metabolic syndrome
diminazene
Ang II
TLR4
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.904756/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.904756/full

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