Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas

Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas

The effects of the LDH-A depletion via shRNA knockdown on three murine glioma cell lines and corresponding intracranial (i.c.) tumors were studied and compared to pharmacologic (GNE-R-140) inhibition of the LDH enzyme complex, and to shRNA scrambled control (NC) cell lines. The effects of genetic-sh...

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Bibliographic Details
Main Authors: Masatomo Maeda, Myat Ko, Mayuresh M. Mane, Ivan J. Cohen, Masahiro Shindo, Kiranmayi Vemuri, Inna Serganova, Ronald Blasberg
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
glioblastoma
LDH-A shRNA knockdown
GNE-R-140
LDH isoenzymes
LDH-A and LDH-B immunohistochemistry
tumor growth
Online Access:https://www.mdpi.com/2072-6694/14/9/2306

Internet

https://www.mdpi.com/2072-6694/14/9/2306

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