Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3–Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit

Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3–Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit

Drug resistance is a major obstacle to successful cancer treatment. Therefore, it is essential to understand the molecular mechanisms underlying drug resistance to develop successful therapeutic strategies. α6β4 integrin confers resistance to apoptosis and regulates the survival of cancer cells; how...

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Bibliographic Details
Main Authors: Yoshinobu Kariya, Jianguo Gu, Yukiko Kariya
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomolecules
Subjects:
α6β4 integrin
doxorubicin
chemoresistance
caspase-3
N-acetylglucosaminyltransferase III (GnT-III)
bisecting GlcNAc
Online Access:https://www.mdpi.com/2218-273X/13/12/1752

Internet

https://www.mdpi.com/2218-273X/13/12/1752

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