Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins

Measles virus undergoes error-prone replication like other RNA viruses, but over time, it has remained antigenically monotypic. The constraints on the virus that prevent the emergence of antigenic variants are unclear. As a first step in understanding this question, we subjected the measles virus ge...

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Bibliographic Details
Main Authors: Benjamin O. Fulton, David Sachs, Shannon M. Beaty, Sohui T. Won, Benhur Lee, Peter Palese, Nicholas S. Heaton
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715004714