Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1.

Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1.

BACKGROUND: The cellular and molecular mechanisms of tumour response following chemotherapy are largely unknown. We found that low dose anti-tumour agents up-regulate early growth response 1 (EGR1) expression. EGR1 is a member of the immediate-early gene group of transcription factors which modulate...

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Bibliographic Details
Main Authors: Yukihiro Matsunoshita, Kosei Ijiri, Yasuhiro Ishidou, Satoshi Nagano, Takuya Yamamoto, Hiroko Nagao, Setsuro Komiya, Takao Setoguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3024416?pdf=render

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http://europepmc.org/articles/PMC3024416?pdf=render

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