Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

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Abstract Growing evidence supports that LKB1‐deficient KRAS‐driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity that promotes lineage conversion and drug resistance. Here we find that murine lung tumors from the KrasLSL‐G12D/+; Lkb1flox/flox (KL) model sh...

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Bibliographic Details
Main Authors: Xinyuan Tong, Yueqing Chen, Xinsheng Zhu, Yi Ye, Yun Xue, Rui Wang, Yijun Gao, Wenjing Zhang, Weiqiang Gao, Lei Xiao, Haiquan Chen, Peng Zhang, Hongbin Ji
Format: Article
Language:English
Published: Springer Nature 2021-01-01
Series:EMBO Molecular Medicine
Subjects:
drug resistance
gastric differentiation
LKB1
Nanog
Notch
Online Access:https://doi.org/10.15252/emmm.202012627

Internet

https://doi.org/10.15252/emmm.202012627

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