The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation

Summary: Cells activate stress response pathways to survive adverse conditions. Such responses involve the inhibition of global cap-dependent translation. This inhibition is a block that essential transcripts must escape via alternative methods of translation initiation, e.g., an internal ribosome e...

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Bibliographic Details
Main Authors: Meghan T. Harris, Michael T. Marr, II
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012950