Identification of MKNK1 and TOP3A as ovarian endometriosis risk-associated genes using integrative genomic analyses and functional experiments

Identification of MKNK1 and TOP3A as ovarian endometriosis risk-associated genes using integrative genomic analyses and functional experiments

The risk of endometriosis (EM), which is a common complex gynaecological disease, is related to genetic predisposition. However, it is unclear how genetic variants confer the risk of EM. Here, via Sherlock integrative analysis, we combined large-scale genome-wide association studies (GWAS) summary s...

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Bibliographic Details
Main Authors: Yizhou Huang, Jie Luo, Yue Zhang, Tao Zhang, Xiangwei Fei, Liqing Chen, Yingfan Zhu, Songyue Li, Caiyun Zhou, Kaihong Xu, Yunlong Ma, Jun Lin, Jianhong Zhou
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Endometriosis
Risk genes
Genome-wide association study
Expression quantitative trait loci
Integrative genomics analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023000478

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http://www.sciencedirect.com/science/article/pii/S2001037023000478

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